Anterior vaginal prolapse AVP is the most common form of pelvic organ prolapse POP and has deleterious effects on women's health. Despite recent advances in AVP diagnosis and treatment, a cell atlas of the vaginal wall in AVP has not been constructed. Here, we employ single-cell RNA-seq to construct a transcriptomic atlas of 81, individual cells in the vaginal wall from AVP and control samples and identify 11 cell types. We reveal aberrant gene expression in diverse cell types in AVP. Extracellular matrix ECM dysregulation and immune reactions involvement are identified in both non-immune and immune cell types.
Vaginal Prolapse - Causes, Types, Pessary Device, Surgery & Transvaginal Mesh | Everyday Health
Learn what can cause the vagina and other pelvic organs to fall from their normal position. Vaginal prolapse happens when the vagina falls from its normal location inside the pelvis toward the opening of the vagina. In severe cases of prolapse, the vagina may protrude outside the vaginal opening. Vaginal prolapse seldom involves just the vagina. Other pelvic organs, including the uterus and bladder, can also fall out of place. This condition may be referred to, collectively, as pelvic organ prolapse. The vagina and other pelvic organs are held in place by muscles and connective tissue.
There are many types of prolapse, which differ according to which organ is affected. When the walls of the vagina become lax, the organs that they should be supporting bulge into the vagina, creating the sensation of a lump hanging down. The uterus is supported at the top of the vagina, and when the ligaments in this wall loosen, the uterus bulges downward.
Medically reviewed by Drugs. Last updated on February 28, The uterus and the bladder are held in their normal positions just above the inside end of the vagina by a "hammock" made up of supportive muscles and ligaments.